Prescient Medical, Inc. Presents Clinical And Preclinical Findings For VProtect(TM) Luminal Shield And VPredict(TM) Optical Catheter System

TCT 2008 attendees will be
among the first to hear a report on initial clinical experiences with the
vProtect(TM) Luminal Shield in patients with non-flow-limiting "vulnerable"
plaques. Professor Patrick Serruys, Director of Clinical Research and chief
of interventional cardiology at the Erasmus Medical Center in Rotterdam,
the Netherlands, will present early findings and describe the rationale and
design of the SECRITT I trial, a randomized pilot study of the device in
patients with vulnerable plaque. According to Prof. Serruys, "Vulnerable
plaques can rupture suddenly, and with catastrophic results. If the
vProtect(TM) Luminal Shield can gently stabilize these plaques, as it is
designed to do, it will be a break-through, a paradigm shift in
interventional cardiology." Prof. Serruys's presentation, "Progress with a
Vulnerable Plaque Shield and a 'Secret' Trial," is scheduled for 4:18 pm,
Monday October 13, in room 152A of the Walter E. Washington Convention
Center, Washington DC.



Its unique self-expanding and biocompatible design makes the
vProtect(TM) Luminal Shield a potentially attractive alternative to
traditional stents in established indications. Juan Granada, MD, will
present details on the innovative design of the vProtect(TM) Luminal Shield
and an update on the ongoing first-in-human study of the Shield at 11:52 am
on Monday October 13, in room 145AB of the Washington Convention Center.



Prescient Medical is also spearheading an effort to better identify and
characterize vulnerable plaques, a project that strongly complements the
vProtect(TM) Luminal Shield development program. Guillermo Tearney, MD,
PhD, of the Wellman Center for Photomedicine, Massachusetts General
Hospital, will present new results related to the use of the vPredict(TM)
Optical Catheter System for characterizing vulnerable plaques at TCT 2008.
The vPredict(TM) platform is based on Raman spectroscopy, a highly
sensitive technique that is used in scores of critical non-clinical
applications. "The vPredict(TM) Optical Catheter System can detect the
spectroscopic 'fingerprints' of compounds in the plaque. Our task is to
correlate the spectra we obtain to histology, so that we can classify a
plaque, and ultimately assess its risk of rupture in vivo, based on the
results of the Optiography(TM) Scan," explained Dr. Tearney. The
presentation, titled "The Promise and Reality of Raman Spectroscopy for
Atherosclerosis Imaging: Advantages and Limitations," will be held at 1:44
pm, Monday October 13, in room 152A of the Washington Convention Center.



Recent preclinical results with the vPredict(TM) Optical Catheter
System will be available through the duration of TCT 2008 via e-poster
kiosks. The e-poster presentation, "Discrimination Between Cholesterol and
Cholesterol Esters in Coronary Artery Tissue with Raman Spectroscopy," was
authored by Jon Nazemi, MS, and James F. Brennan III, PhD.



About Prescient Medical, Inc.



Prescient Medical, Inc. is a privately held medical device company
dedicated to reducing deaths from heart attacks and cardiovascular disease,
the leading causes of death in much of the world.


Prescient Medical, Inc.

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